Developmental nonlinearity drives phenotypic robustness
نویسندگان
چکیده
منابع مشابه
Phenotypic diversity drives paracrine drug tolerance
Considerable clinical successes have been achieved in cancer treatment since the introduction of targeted therapies. However, almost inevitably tumors develop therapy resistance, which limits durable clinical responses. Tumors are often heterogeneous, and as a result, therapy-resistant cells are present even before the start of treatment. Resistance is commonly mediated via genetic changes. How...
متن کاملThe Quantitative Genetics of Phenotypic Robustness
Phenotypic robustness, or canalization, has been extensively investigated both experimentally and theoretically. However, it remains unknown to what extent robustness varies between individuals, and whether factors buffering environmental variation also buffer genetic variation. Here we introduce a quantitative genetic approach to these issues, and apply this approach to data from three species...
متن کاملEnzyme isoforms may increase phenotypic robustness.
Enzyme isoforms are found in many cellular reactions, and can differ in the kind of reaction they catalyze, in their substrate affinity, or in their reaction rates. The evolutionary significance of enzyme isoforms is only partially understood. We used mathematical modeling to investigate the hypothesis that isoforms may be favored by selection because they can increase the phenotypic robustness...
متن کاملChromatin regulators, phenotypic robustness, and autism risk
Though extensively characterized clinically, the causes of autism spectrum disorder (ASD) remain a mystery. ASD is known to have a strong genetic basis, but it is genetically very heterogeneous. Recent studies have estimated that de novo disruptive mutations in hundreds of genes may contribute to ASD. However, it is unclear how it is possible for mutations in so many different genes to contribu...
متن کاملDevelopmental mappings and phenotypic complexity
The effect of phenotypic complexity on distance correlation plots is investigated for two developmental mappings, a mapping based on L-systems, and a 2D cellular automata mapping. Our treatment of complexity is based on the theory of Kolmogorov complexity. A new genotype sampling algorithm called Crossection Walk is introduced.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Communications
سال: 2017
ISSN: 2041-1723
DOI: 10.1038/s41467-017-02037-7